'Mass vaccination against the pandemic influenza A/H1N1 infection fell short on expected results, according to a study published in the British Medical Journal. Researchers examined a cohort of 388,069 patients younger than 65 years old, who were given the H1N1 vaccination between November 2009 and January 2010 when the transmission of pandemic influenza was spreading rapidly.
The researchers used proportional hazards regression models to assess the efficacy of the pandemic vaccine. Study outcomes confirmed H1N1 and flu-related admissions diagnosed as the H1N1 infection. The experts then further arranged the models into four variables including age group, number of chronic illnesses, seasonal vaccine status and pandemic vaccine status. Data showed that coverage for both the pandemic influenza vaccine and the 2009-2010 seasonal influenza vaccine varied between age groups, with the lowest coverage rates found in the youngest age groups, aged 39 years and below.
Researchers also found that more than 80 percent of the cohort had only one diagnosed underlying condition. Vaccine uptake, which simultaneously increased for both pandemic and seasonal influenza vaccines, was higher when more chronic conditions were diagnosed. Furthermore, H1N1 infections also appeared to increase when more chronic conditions were identified.
More than a fifth of the cohort received at least one dose of the pandemic vaccine, 46 percent of whom took their first dose during the first week of the vaccine’s availability. Researchers also found that more than half of the people in the group received only one dose of the pandemic vaccine, while a little more than 40 percent received two doses.'
Read more: Mass vaccination for influenza a failed strategy, scientists admit… it simply doesn’t reduce influenza-related hospital admissions at all
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